Alternate splicing results in multiple transcript variants. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Go to EMA Acccount Management ( Click on 'Create a new EMA account' which will open an EMA - Self-service registration form Complete the EMA Self-service Registration Form and click on Register Note: Access to IRIS as an Individual User is now granted by default. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. These proteins also play a role in intracellular signaling. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. This gene encodes a membrane-bound protein that is a member of the mucin family.MUC1 mucin 1, cell surface associated mucin 1, transmembrane, PUM mucin-1 CD227 PEM episialin DF3 antigen H23 antigen krebs von den Lungen-6 mucin 1, transmembrane tumor-associated mucin carcinoma-associated mucin polymorphic epithelial mucin peanut-reactive urinary mucin tumor associated epithelial mucin breast carcinoma-associated antigen DF3 tumor-associated epithelial membrane antigen EMA PUM KL-6 MAM6 PEMT H23AG MUC-1 MUC-1/X MUC1/ZD MUC-1/SEC Log in to the sponsor workspace using your EMA account.Biparatopic Receptor-based Bispecific ADCs.Fast-internalizing Receptor-based Bispecific ADCs.Antibody Fragment-drug Conjugates Development.Application of Antibody-Oligonucleotide Conjugates (AOC).Conjugation Strategies of AOC Development.Oligonucleotide Synthesis for AOC Development.Antibody-Oligonucleotide Conjugates (AOC) Development Services.The quality and functionality of chemical linkers have. Antibody-directed Enzyme Prodrug Therapy (ADEPT) ADC, Mylotarg was never approved for cancer treatment by the European Medicines Agency (EMA).

Antibody Discovery Service for Enzyme Conjugate.Approximate drug-antibody ratios for each ADC are represented. Schematic diagrams of EMA and FDA-approved ADCs for haematological cancers binding to their target cells. Antibody-directed Toxic Enzyme Fusion Proteins ADC Targets for Haematological Malignancies.Antibody-enzyme Conjugates for Cancer Therapy.Antibody Discovery for Bacterial Infection.

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